Biomimetic PVPA in vitro model for estimation of the intestinal drug permeability using fasted and fed state simulated intestinal fluids
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منابع مشابه
Biomimetic PVPA in vitro model for estimation of the intestinal drug permeability using fasted and fed state simulated intestinal fluids.
A prerequisite for successful oral drug therapy is the drug's ability to cross the gastrointestinal barrier. Considering the increasing number of new chemical entities in modern drug discovery, reliable and fast in vitro models are required for early and efficient prediction of intestinal permeability. To mimic the intestinal environment, use of biorelevant media may provide valuable informatio...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutical Sciences
سال: 2015
ISSN: 0928-0987
DOI: 10.1016/j.ejps.2015.03.017